AI and biology are expanding what humanity can build faster than our institutions can learn to steer them.

In government & policy

Dept. of DefenseNational AcademiesNSCEB

I work to build the future I want to live in, because it isn’t here yet.

CurrentlyCEO, Vigilance at Alloy TherapeuticsAlso building
01The argument

Safety and speed are not opposites.

The discipline that makes a technology trustworthy is the same one that lets you ship it. AI and biotech are moving faster than the systems meant to govern them, and the reflex is to slow down or look away. Build the responsibility in from the start, the way you would build in security, and you earn the right to move.

We cannot prove an absence of risk, but we can build empirical ways to measure change over time.
Written testimony · U.S. Senate AI Insight Forum · 2023
02The record

This isn’t theoretical.

Alexander Titus

More than a decade building and governing AI and biotech from inside the institutions that decide what happens to them.

2026

Vigilance Division, Alloy Therapeutics

Chief Executive Officer

Building the division that turns Alloy’s platform into biosecurity countermeasures the country can actually deploy.

2025

National Security Commission on Emerging Biotechnology

Commissioner, appointed by Congress

Charting the Future of Biotechnology, the national action plan for keeping the country ahead in biotech, delivered to Congress.

2025

National Academies of Sciences, Engineering, and Medicine

Consensus study committee

The Age of AI in the Life Sciences: Benefits and Biosecurity Considerations.

2024

Avidity Biosciences

Vice President, AI & Machine Learning

Built the company’s first enterprise AI organization and put it to work across drug discovery and the business.

2023

U.S. Senate AI Insight Forum

Invited expert testimony

Testimony on measuring the risk of AI in biology instead of guessing.

2022

Colossal Biosciences

Entrepreneur-in-Residence and VP, Strategy & Computational Sciences

Turns out you can change a tiger’s stripes these days.

2021

Google Public Sector

Head of Healthcare & Life Sciences Strategy

Scaled the Intelligent Vaccine Impact solution to more than thirty state and national governments during the COVID-19 response.

2019

U.S. Department of Defense

Inaugural head of biotechnology strategy

Built the Pentagon’s first enterprise biotechnology strategy, the groundwork that launched BioMADE.

2017

Amazon

Research Fellow, Alexa AI

A research fellowship in applied machine learning, understanding the nuance of machine language before Large Language Models (LLMs).

03The writing

The part I can’t put in a policy paper.

A memo can warn you about a future. A novel puts you inside it. I write speculative fiction about the ethics of the technology I work on: the futures I’m trying to prevent, and a few I’m rooting for.

Forthcoming · Fall 2026

Monarch

A four-book series

A system full of responsible people, all making defensible choices, that still turns on the people it was built to protect.

Evil rarely comes with a cackling smile. Sometimes it comes in a spreadsheet.
Alexander Titus cycling a mountain road on the 2 Wheels, 2 Continents expedition
Outside the room

Away from the desk I go looking for the edge of what I can do, on foot, on a bike, up high. The reasons are the same as the work. Ideas have to survive contact with reality. The limits other people accept are not yours to inherit. You build real capability by walking into uncertainty and finding your way out.

04What comes next

The next ten years of AI and biology will be the most consequential we’ve had. Most of it won’t be settled in a lab.

It comes down to whether the people building the technology and the people writing its rules are ever in the same room. I’ve spent my career trying to be in both. There’s more to do.

Essays when I’ve got something worth saying, and word when the next book is out. Unsubscribe anytime.

For work, speaking, or press, find me on LinkedIn.